Welcome to 77CBD, your go-to source for all things CBD Oil UK! Today, we’re diving into the world of CBD as it relates to cancer treatment, based on Dr. Joe D. Goldstrich and Angela Bacca’s latest book, The Cannabis Cancer Connection: How to use cannabis and hemp to kill cancer cells (Flower Valley Press, 2023).
The evidence is clear – both anecdotal and scientific – that certain cannabinoids such as THC and CBD, along with other compounds found in cannabis, have powerful antineoplastic effects on cancer cells. While much of the research has historically focused on the effects of individual cannabinoids on cancer cells, there is a growing body of work that suggests that the combination of compounds found in whole-plant cannabis, including hemp varieties, holds significant potential in combating cancer.
When it comes to THC, the primary psychoactive compound in cannabis, research indicates that it binds to cancer cell receptors, inducing apoptosis or programmed cell death. This action also helps alleviate pain, as THC binds to both CB1 and CB2 receptors found in the body. Furthermore, THC limits tumor growth by inhibiting the production of vascular endothelial growth factor, crucial for cancer development.
On the other hand, CBD, a non-psychoactive compound, exhibits apoptotic, anti-proliferative, and anti-invasive activities. Despite not directly binding to cannabinoid receptors, CBD is shown to downregulate the ID-1 gene, which is related to cancer cell growth, survival, and metastasis. CBD also blocks the production of vascular endothelial growth factor and inhibits cancer cell migration and metastases.
Moreover, combining THC and CBD has shown significant promise in combating various types of cancer cells. Studies have demonstrated that this combination was twice as powerful as either cannabinoid alone, particularly in killing leukemia cells. Additionally, combining different cannabinoids such as CBD and CBG also proved to be a potent strategy in cancer treatment.
In the realm of clinical studies, GW Pharmaceuticals, a leading company in cannabis-based medicine, conducted a phase 2 clinical trial using Sativex®, a THC and CBD-based medicine, in conjunction with temozolomide to treat recurrent glioblastoma multiforme (GBM), a highly aggressive brain tumor. The results were very promising, showing a significant increase in survival rates for patients utilizing the Sativex® and temozolomide combination.
As we continue to delve deeper into the potential of CBD and cannabis in cancer treatment, it is clear that whole-plant cannabis, with its various compounds and entourage effect, holds great promise. With ongoing research and clinical trials, we can hope to unlock the full potential of CBD and cannabis in fighting cancer. Stay tuned for more cutting-edge reviews and insights from 77CBD!